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This article I'm posting the link to below, from The Journal of Clinical Endocrinology & Metabolism, is entitled: "In Search of the Impossible Dream? Thyroid Hormone Replacement Therapy That Treats All Symptoms in All Hypothyroid Patients"
The article points out the fact that many patients who are on hormone replacement therapy for hypothyroidism, do not always experience significant symptom relief. The article points out a variety of reasons for this problem of unsatifactory results from thyroid medication used to treat hypothyroidism. It also points out the fact that some patients are treated with T-4 only thyroid medications, when some might benefit more from a combination T-4 and T-3 medication. It makes mention of the fact that some patients may be undertreated by their Doctors with their hypothyroid medications in general.
While it is a very interesting study, I feel some mention of the fact that if hypothyroidism has "thyroid autoimmunity" as its cause, the disease itself has potential to cause symptoms apart from hormone levels. There are medical research studies out there that confirm this fact as well, including some listed within this article.

Link>>
http://jcem.endojournals.org/cgi/content/full/88/10/4540